Assay Detail
Binding
CHEMBL875660
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Inhibitory activity against AICAR formyltransferase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Bifunctional purine biosynthesis protein ATIC (CHEMBL2518) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A multisubstrate adduct inhibitor of AICAR transformylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.27 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL608337 | — | — | 1 | 6.90 |
| CHEMBL483849 | — | — | 1 | 4.60 |
| CHEMBL116396 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL608337 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL483849 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL116396 | — | IC50 | = | 50000.0 | nM | 4.30 |