Assay Detail
Functional
CHEMBL875930
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Antagonistic affinity tested against isolated Rat Prostate Alpha-1A adrenergic receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 8.15 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44403 | — | — | 1 | 9.46 |
| CHEMBL25554 | — | — | 1 | 9.27 |
| CHEMBL42472 | — | — | 1 | 8.95 |
| CHEMBL43905 | — | — | 1 | 8.31 |
| CHEMBL297106 | — | — | 1 | 8.23 |
| CHEMBL42558 | — | — | 1 | 7.47 |
| CHEMBL40325 | — | — | 1 | 6.97 |
| CHEMBL42231 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44403 | — | Kd | = | 0.3467 | nM | 9.46 |
| CHEMBL25554 | — | Kd | = | 0.537 | nM | 9.27 |
| CHEMBL42472 | — | Kd | = | 1.122 | nM | 8.95 |
| CHEMBL43905 | — | Kd | = | 4.898 | nM | 8.31 |
| CHEMBL297106 | — | Kd | = | 5.888 | nM | 8.23 |
| CHEMBL42558 | — | Kd | = | 33.88 | nM | 7.47 |
| CHEMBL40325 | — | Kd | = | 107.15 | nM | 6.97 |
| CHEMBL42231 | — | Kd | = | 288.4 | nM | 6.54 |