Assay Detail
Binding
CHEMBL876400
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Evaluated for inhibitory activity against RBL-1 cell 5-lipoxygenase in guinea pig
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A study of novel antiallergic agents with eosinophilic infiltration inhibiting action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.18 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL543356 | — | — | 1 | 6.46 |
| CHEMBL538756 | — | — | 1 | 6.45 |
| CHEMBL539525 | — | — | 1 | 6.37 |
| CHEMBL544064 | — | — | 1 | 6.28 |
| CHEMBL542889 | — | — | 1 | 6.09 |
| CHEMBL545708 | — | — | 1 | 5.97 |
| CHEMBL538258 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL543356 | — | IC50 | = | 351.0 | nM | 6.46 |
| CHEMBL538756 | — | IC50 | = | 358.0 | nM | 6.45 |
| CHEMBL539525 | — | IC50 | = | 426.0 | nM | 6.37 |
| CHEMBL544064 | — | IC50 | = | 526.0 | nM | 6.28 |
| CHEMBL542889 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL545708 | — | IC50 | = | 1065.0 | nM | 5.97 |
| CHEMBL538258 | — | IC50 | = | 2215.0 | nM | 5.66 |