Assay Detail
Functional
CHEMBL876415
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Inhibition of integrin alpha-v/beta-5 mediated UCLAP-3 cell adhesion on vitronectin
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | UCLAP-3 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.12 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429876 | CILENGITIDE | 3.0 | 1 | 6.40 |
| CHEMBL9737 | — | — | 1 | 5.92 |
| CHEMBL2372331 | — | — | 1 | 5.89 |
| CHEMBL9200 | — | — | 1 | 5.70 |
| CHEMBL2372407 | — | — | 1 | 5.68 |
| CHEMBL268056 | — | — | 1 | 5.30 |
| CHEMBL9508 | — | — | 1 | 4.75 |
| CHEMBL267434 | — | — | 1 | 4.70 |
| CHEMBL417426 | — | — | 1 | 4.68 |
| CHEMBL417066 | — | — | 1 | 4.62 |
| CHEMBL9555 | — | — | 1 | 4.58 |
| CHEMBL9278 | — | — | 1 | 4.57 |
| CHEMBL2372398 | — | — | 1 | 4.51 |
| CHEMBL266151 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429876 | CILENGITIDE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL9737 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2372331 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL9200 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2372407 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL268056 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL9508 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL267434 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL417426 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL417066 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL9555 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL9278 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL2372398 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL266151 | — | IC50 | = | 43000.0 | nM | 4.37 |