Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL876478

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against CDK1/ Cyclin B
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 6 — Multiple protein complex / RNA
Curated By Autocuration

Target

Cyclin-dependent kinase 1/cyclin B1 (CHEMBL1907602)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

2-Aminoquinazoline inhibitors of cyclin-dependent kinases.
Bathini Y, Singh I, Harvey PJ, Keller PR, Singh R, Micetich RG, Fry DW, Dobrusin EM, Toogood PL.
Bioorg Med Chem Lett (2005) 15 : 3881 -3885
PubMed 15993068 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 6.25 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL360342 1 7.52
CHEMBL180431 1 6.88
CHEMBL182843 1 6.67
CHEMBL359951 1 6.57
CHEMBL181416 1 6.40
CHEMBL182641 1 6.30
CHEMBL182498 1 6.13
CHEMBL361987 1 6.12
CHEMBL183455 1 6.10
CHEMBL360250 1 6.10
CHEMBL180993 1 6.09
CHEMBL359679 1 5.98
CHEMBL183511 1 5.89
CHEMBL361958 1 5.80
CHEMBL182011 1 5.71
CHEMBL180341 1 5.71
CHEMBL181323 1 -
CHEMBL183269 1 -
CHEMBL181834 1 -
CHEMBL183200 1 -
CHEMBL361769 1 -
CHEMBL183855 1 -
CHEMBL360675 1 -
CHEMBL181803 1 -
CHEMBL361621 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL360342 IC50 = 30.0 nM 7.52
CHEMBL180431 IC50 = 132.0 nM 6.88
CHEMBL182843 IC50 = 214.0 nM 6.67
CHEMBL359951 IC50 = 270.0 nM 6.57
CHEMBL181416 IC50 = 398.0 nM 6.40
CHEMBL182641 IC50 = 506.0 nM 6.30
CHEMBL182498 IC50 = 743.0 nM 6.13
CHEMBL361987 IC50 = 761.0 nM 6.12
CHEMBL183455 IC50 = 801.0 nM 6.10
CHEMBL360250 IC50 = 800.0 nM 6.10
CHEMBL180993 IC50 = 813.0 nM 6.09
CHEMBL359679 IC50 = 1040.0 nM 5.98
CHEMBL183511 IC50 = 1300.0 nM 5.89
CHEMBL361958 IC50 = 1590.0 nM 5.80
CHEMBL182011 IC50 = 1970.0 nM 5.71
CHEMBL180341 IC50 = 1940.0 nM 5.71
CHEMBL181323 IC50 > 5000.0 nM -
CHEMBL183269 IC50 > 5000.0 nM -
CHEMBL181834 IC50 > 5000.0 nM -
CHEMBL183200 IC50 > 5000.0 nM -
CHEMBL361769 IC50 > 5000.0 nM -
CHEMBL183855 IC50 > 5000.0 nM -
CHEMBL360675 IC50 > 5000.0 nM -
CHEMBL181803 IC50 > 5000.0 nM -
CHEMBL361621 IC50 > 5000.0 nM -