Assay Detail
Binding
CHEMBL876558
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Displacement of [3H]CHA from rat brain adenosine receptor
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Publication
C4-substituted 1-beta-D-ribofuranosylpyrazolo[3,4-d]pyrimidines as adenosine agonist analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.88 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45891 | — | — | 1 | 8.62 |
| CHEMBL139000 | (R)-PIA | — | 2 | 8.43 |
| CHEMBL605654 | — | — | 1 | 8.40 |
| CHEMBL605067 | — | — | 1 | 4.70 |
| CHEMBL605655 | — | — | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45891 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL139000 | (R)-PIA | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL605654 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL139000 | (R)-PIA | IC50 | = | 95.7 | nM | 7.02 |
| CHEMBL605067 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL605655 | — | IC50 | = | 76500.0 | nM | 4.12 |