Assay Detail
Binding
CHEMBL876562
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Bnding affinity in membrane of CHO cell stably expressing recombinant human Adenosine A3 receptor using [3H]8-ethyl-4-methyl-2-phenyl-(8R)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]-purin-5-one as radioligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.20 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88147 | — | — | 1 | 8.92 |
| CHEMBL342873 | — | — | 1 | 8.57 |
| CHEMBL307199 | — | — | 1 | 8.49 |
| CHEMBL344187 | — | — | 1 | 7.58 |
| CHEMBL284969 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88147 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL342873 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL307199 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL344187 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL284969 | — | Ki | = | 38.0 | nM | 7.42 |