Assay Detail
Binding
CHEMBL876710
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Inhibitory activity was determined against dihydrofolate reductase in Pneumocystis carinii.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pneumocystis carinii |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.40 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145628 | — | — | 1 | 8.22 |
| CHEMBL50514 | — | — | 1 | 7.89 |
| CHEMBL23532 | — | — | 1 | 7.89 |
| CHEMBL145221 | — | — | 1 | 7.46 |
| CHEMBL142345 | — | — | 1 | 6.72 |
| CHEMBL145579 | — | — | 1 | 6.72 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.06 |
| CHEMBL322585 | — | — | 1 | 5.92 |
| CHEMBL141997 | — | — | 1 | 5.85 |
| CHEMBL1043 | DAPSONE | 4.0 | 1 | 5.82 |
| CHEMBL357573 | — | — | 1 | 5.55 |
| CHEMBL423939 | — | — | 1 | 5.51 |
| CHEMBL141548 | — | — | 1 | 5.02 |
| CHEMBL145060 | — | — | 1 | 4.97 |
| CHEMBL343630 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145628 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL50514 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL23532 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL145221 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL142345 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL145579 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL322585 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL141997 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1043 | DAPSONE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL357573 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL423939 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL141548 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL145060 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL343630 | — | IC50 | = | 120000.0 | nM | - |