Assay Detail
Binding
CHEMBL876759
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In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Comparison of 3D structures and AT(1) binding properties of pyrazolidine-3,5-diones and tetrahydropyridazine-3,6-diones with parent antihypertensive drug irbesartan.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.81 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1513 | IRBESARTAN | 4.0 | 1 | 8.70 |
| CHEMBL358359 | — | — | 1 | 7.85 |
| CHEMBL315444 | — | — | 1 | 7.60 |
| CHEMBL146275 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1513 | IRBESARTAN | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL358359 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL315444 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL146275 | — | Ki | = | 80.0 | nM | 7.10 |