Assay Detail
Binding
CHEMBL876765
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Binding affinity against Alpha-1A adrenergic receptor (recombinant human receptor) using [3H]prazosin.
26
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 4. Structure-activity relationship in the dihydropyrimidine series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 8.97 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145411 | — | — | 1 | 10.00 |
| CHEMBL142981 | — | — | 1 | 10.00 |
| CHEMBL141322 | — | — | 3 | 10.00 |
| CHEMBL5483012 | — | — | 1 | 9.70 |
| CHEMBL145770 | — | — | 1 | 9.52 |
| CHEMBL144534 | — | — | 1 | 9.40 |
| CHEMBL359421 | — | — | 1 | 9.40 |
| CHEMBL141604 | — | — | 1 | 9.40 |
| CHEMBL145587 | — | — | 1 | 9.40 |
| CHEMBL145746 | — | — | 1 | 9.40 |
| CHEMBL357842 | — | — | 1 | 9.30 |
| CHEMBL436407 | — | — | 1 | 9.30 |
| CHEMBL357828 | — | — | 1 | 9.22 |
| CHEMBL145001 | — | — | 1 | 9.00 |
| CHEMBL142606 | — | — | 1 | 8.96 |
| CHEMBL145178 | — | — | 1 | 8.92 |
| CHEMBL357131 | — | — | 1 | 8.80 |
| CHEMBL358313 | — | — | 1 | 8.46 |
| CHEMBL145278 | — | — | 1 | 8.44 |
| CHEMBL145353 | — | — | 1 | 8.38 |
| CHEMBL144731 | — | — | 1 | 8.17 |
| CHEMBL142719 | — | — | 1 | 7.85 |
| CHEMBL342347 | — | — | 1 | 7.70 |
| CHEMBL359430 | — | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL142981 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL141322 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL145411 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL5483012 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL145770 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL144534 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL145746 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL359421 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL145587 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL141604 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL357842 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL436407 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL357828 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL141322 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL145001 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL142606 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL145178 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL357131 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL358313 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL145278 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL145353 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL144731 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL141322 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL142719 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL342347 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL359430 | — | Ki | = | 22.0 | nM | 7.66 |