Assay Detail
Functional
CHEMBL876778
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Inhibitory concentration against camptothecin induced apoptosis in neuronal precursor (NT2) whole cells
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NT2 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 8.70 | 10.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361825 | — | — | 1 | 10.68 |
| CHEMBL366927 | — | — | 1 | 10.68 |
| CHEMBL362074 | — | — | 1 | 10.60 |
| CHEMBL179503 | — | — | 1 | 10.57 |
| CHEMBL369290 | — | — | 1 | 10.11 |
| CHEMBL359598 | — | — | 1 | 9.89 |
| CHEMBL178514 | — | — | 1 | 9.82 |
| CHEMBL434147 | — | — | 1 | 9.54 |
| CHEMBL181623 | — | — | 1 | 9.52 |
| CHEMBL179551 | — | — | 1 | 9.52 |
| CHEMBL424789 | — | — | 1 | 9.08 |
| CHEMBL425699 | — | — | 1 | 9.00 |
| CHEMBL181274 | — | — | 1 | 8.92 |
| CHEMBL360788 | — | — | 1 | 8.90 |
| CHEMBL180623 | — | — | 1 | 8.86 |
| CHEMBL433771 | — | — | 1 | 8.86 |
| CHEMBL181763 | — | — | 1 | 8.85 |
| CHEMBL178674 | — | — | 1 | 8.84 |
| CHEMBL367356 | — | — | 1 | 8.82 |
| CHEMBL264344 | — | — | 1 | 8.81 |
| CHEMBL441118 | — | — | 1 | 8.79 |
| CHEMBL181027 | — | — | 1 | 8.58 |
| CHEMBL181768 | — | — | 1 | 8.51 |
| CHEMBL180273 | — | — | 1 | 8.47 |
| CHEMBL360355 | — | — | 1 | 8.45 |
| CHEMBL181396 | — | — | 1 | 8.41 |
| CHEMBL181295 | — | — | 1 | 8.40 |
| CHEMBL361613 | — | — | 1 | 8.34 |
| CHEMBL178339 | — | — | 1 | 8.29 |
| CHEMBL178116 | — | — | 1 | 8.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361825 | — | IC50 | = | 0.021 | nM | 10.68 |
| CHEMBL366927 | — | IC50 | = | 0.021 | nM | 10.68 |
| CHEMBL362074 | — | IC50 | = | 0.025 | nM | 10.60 |
| CHEMBL179503 | — | IC50 | = | 0.027 | nM | 10.57 |
| CHEMBL369290 | — | IC50 | = | 0.078 | nM | 10.11 |
| CHEMBL359598 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL178514 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL434147 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL181623 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL179551 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL424789 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL425699 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL181274 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL360788 | — | IC50 | = | 1.25 | nM | 8.90 |
| CHEMBL433771 | — | IC50 | = | 1.39 | nM | 8.86 |
| CHEMBL180623 | — | IC50 | = | 1.38 | nM | 8.86 |
| CHEMBL181763 | — | IC50 | = | 1.42 | nM | 8.85 |
| CHEMBL178674 | — | IC50 | = | 1.45 | nM | 8.84 |
| CHEMBL367356 | — | IC50 | = | 1.52 | nM | 8.82 |
| CHEMBL264344 | — | IC50 | = | 1.53 | nM | 8.81 |
| CHEMBL441118 | — | IC50 | = | 1.62 | nM | 8.79 |
| CHEMBL181027 | — | IC50 | = | 2.64 | nM | 8.58 |
| CHEMBL181768 | — | IC50 | = | 3.08 | nM | 8.51 |
| CHEMBL180273 | — | IC50 | = | 3.42 | nM | 8.47 |
| CHEMBL360355 | — | IC50 | = | 3.56 | nM | 8.45 |
| CHEMBL181396 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL181295 | — | IC50 | = | 3.99 | nM | 8.40 |
| CHEMBL361613 | — | IC50 | = | 4.56 | nM | 8.34 |
| CHEMBL178339 | — | IC50 | = | 5.12 | nM | 8.29 |
| CHEMBL178116 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL360956 | — | IC50 | = | 5.33 | nM | 8.27 |
| CHEMBL181948 | — | IC50 | = | 5.74 | nM | 8.24 |
| CHEMBL180763 | — | IC50 | = | 6.41 | nM | 8.19 |
| CHEMBL359542 | — | IC50 | = | 6.79 | nM | 8.17 |
| CHEMBL361983 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL447233 | — | IC50 | = | 7.09 | nM | 8.15 |
| CHEMBL178280 | — | IC50 | = | 8.06 | nM | 8.09 |
| CHEMBL179066 | — | IC50 | = | 8.39 | nM | 8.08 |
| CHEMBL362191 | — | IC50 | = | 8.56 | nM | 8.07 |
| CHEMBL178775 | — | IC50 | = | 8.62 | nM | 8.06 |
| CHEMBL360020 | — | IC50 | = | 9.48 | nM | 8.02 |
| CHEMBL360915 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL362213 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL443565 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL181775 | — | IC50 | = | 37.9 | nM | 7.42 |
| CHEMBL182103 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL220238 | — | IC50 | = | 52.1 | nM | 7.28 |
| CHEMBL359643 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL180669 | — | IC50 | = | 0.0027 | nM | - |
| CHEMBL180646 | — | IC50 | = | 0.0048 | nM | - |