Assay Detail
Functional
CHEMBL876930
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In vitro Bone resorption; measuring degradation of bovine bone by isolated osteoclasts
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
A novel class of nonpeptidic biaryl inhibitors of human cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.29 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123227 | — | — | 1 | 7.11 |
| CHEMBL2111806 | — | — | 1 | 7.02 |
| CHEMBL184514 | — | — | 1 | 7.02 |
| CHEMBL123200 | — | — | 1 | 6.92 |
| CHEMBL122879 | — | — | 1 | 6.85 |
| CHEMBL122149 | — | — | 1 | 6.79 |
| CHEMBL334074 | — | — | 1 | 6.70 |
| CHEMBL122324 | — | — | 1 | 6.60 |
| CHEMBL123037 | — | — | 1 | 6.57 |
| CHEMBL123199 | — | — | 1 | 6.47 |
| CHEMBL123038 | — | — | 1 | 6.31 |
| CHEMBL333413 | — | — | 1 | 6.26 |
| CHEMBL126152 | — | — | 1 | 5.91 |
| CHEMBL121807 | — | — | 1 | 5.85 |
| CHEMBL122318 | — | — | 1 | 5.56 |
| CHEMBL333716 | — | — | 1 | 5.55 |
| CHEMBL122764 | — | — | 1 | 5.45 |
| CHEMBL122812 | — | — | 1 | 5.31 |
| CHEMBL421457 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123227 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL2111806 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL184514 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL123200 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL122879 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL122149 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL334074 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL122324 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL123037 | — | IC50 | = | 267.0 | nM | 6.57 |
| CHEMBL123199 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL123038 | — | IC50 | = | 489.0 | nM | 6.31 |
| CHEMBL333413 | — | IC50 | = | 552.0 | nM | 6.26 |
| CHEMBL126152 | — | IC50 | = | 1235.0 | nM | 5.91 |
| CHEMBL121807 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL122318 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL333716 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL122764 | — | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL122812 | — | IC50 | = | 4870.0 | nM | 5.31 |
| CHEMBL421457 | — | IC50 | = | 6580.0 | nM | 5.18 |