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Assay Detail

CHEMBL876955

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Calpain
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Gallus gallus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Alpha-diketone and alpha-keto ester derivatives of N-protected amino acids and peptides as novel inhibitors of cysteine and serine proteinases.
Angelastro MR, Mehdi S, Burkhart JP, Peet NP, Bey P.
J Med Chem (1990) 33 : 11 -13
PubMed 2296008 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 5.96 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL286722 1 8.00
CHEMBL282374 1 6.40
CHEMBL25945 1 6.22
CHEMBL24283 1 6.16
CHEMBL412423 1 5.52
CHEMBL287136 1 5.40
CHEMBL277191 1 4.04
CHEMBL24309 1 -
CHEMBL26066 1 -
CHEMBL286005 1 -
CHEMBL24108 1 -
CHEMBL26283 1 -
CHEMBL287319 1 -
CHEMBL26056 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL286722 Ki = 10.0 nM 8.00
CHEMBL282374 Ki = 400.0 nM 6.40
CHEMBL25945 Ki = 600.0 nM 6.22
CHEMBL24283 Ki = 700.0 nM 6.16
CHEMBL412423 Ki = 3000.0 nM 5.52
CHEMBL287136 Ki = 4000.0 nM 5.40
CHEMBL277191 Ki = 92000.0 nM 4.04
CHEMBL24309 Ki > 1000000.0 nM -
CHEMBL26066 Ki = 150000.0 nM -
CHEMBL286005 Ki > 2000000.0 nM -
CHEMBL24108 Ki > 180000.0 nM -
CHEMBL26283 Ki = 250000.0 nM -
CHEMBL287319 Ki > 1000000.0 nM -
CHEMBL26056 Ki > 180000.0 nM -