Assay Detail
Binding
CHEMBL876974
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Inhibitory concentration against Akt2 kinase
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.69 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL270847 | — | — | 1 | 6.80 |
| CHEMBL258844 | — | — | 1 | 6.68 |
| CHEMBL425155 | — | — | 1 | 6.61 |
| CHEMBL178468 | — | — | 1 | 6.49 |
| CHEMBL367601 | — | — | 1 | 6.38 |
| CHEMBL182101 | — | — | 1 | 6.21 |
| CHEMBL359864 | — | — | 1 | 5.92 |
| CHEMBL178872 | — | — | 1 | 5.82 |
| CHEMBL181730 | — | — | 1 | 5.76 |
| CHEMBL178445 | — | — | 1 | 5.71 |
| CHEMBL260397 | — | — | 1 | 5.69 |
| CHEMBL369532 | — | — | 1 | 5.56 |
| CHEMBL255212 | — | — | 1 | 5.50 |
| CHEMBL360333 | — | — | 1 | 5.32 |
| CHEMBL368010 | — | — | 1 | 5.18 |
| CHEMBL369094 | — | — | 1 | 5.06 |
| CHEMBL181927 | — | — | 1 | 4.94 |
| CHEMBL361391 | — | — | 1 | 4.89 |
| CHEMBL425338 | — | — | 1 | 4.74 |
| CHEMBL178349 | — | — | 1 | 4.47 |
| CHEMBL178397 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL270847 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL258844 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL425155 | — | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL178468 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL367601 | — | IC50 | = | 422.0 | nM | 6.38 |
| CHEMBL182101 | — | IC50 | = | 613.0 | nM | 6.21 |
| CHEMBL359864 | — | IC50 | = | 1205.0 | nM | 5.92 |
| CHEMBL178872 | — | IC50 | = | 1501.0 | nM | 5.82 |
| CHEMBL181730 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL178445 | — | IC50 | = | 1956.0 | nM | 5.71 |
| CHEMBL260397 | — | IC50 | = | 2057.0 | nM | 5.69 |
| CHEMBL369532 | — | IC50 | = | 2746.0 | nM | 5.56 |
| CHEMBL255212 | — | IC50 | = | 3139.0 | nM | 5.50 |
| CHEMBL360333 | — | IC50 | = | 4811.0 | nM | 5.32 |
| CHEMBL368010 | — | IC50 | = | 6650.0 | nM | 5.18 |
| CHEMBL369094 | — | IC50 | = | 8740.0 | nM | 5.06 |
| CHEMBL181927 | — | IC50 | = | 11410.0 | nM | 4.94 |
| CHEMBL361391 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL425338 | — | IC50 | = | 18360.0 | nM | 4.74 |
| CHEMBL178349 | — | IC50 | = | 33660.0 | nM | 4.47 |
| CHEMBL178397 | — | IC50 | > | 20000.0 | nM | - |