Assay Detail
Binding
CHEMBL876978
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Inhibitory concentration against human Protein kinase B, Akt2
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
RAC-beta serine/threonine-protein kinase (CHEMBL2431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.79 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL271091 | — | — | 1 | 7.19 |
| CHEMBL408151 | — | — | 1 | 6.84 |
| CHEMBL258844 | — | — | 1 | 6.68 |
| CHEMBL272292 | — | — | 1 | 6.55 |
| CHEMBL180231 | — | — | 1 | 6.52 |
| CHEMBL178468 | — | — | 1 | 6.49 |
| CHEMBL180058 | — | — | 1 | 6.48 |
| CHEMBL273160 | — | — | 1 | 6.41 |
| CHEMBL572629 | — | — | 1 | 5.93 |
| CHEMBL3143722 | — | — | 1 | 5.76 |
| CHEMBL181419 | — | — | 1 | 5.73 |
| CHEMBL260397 | — | — | 1 | 5.68 |
| CHEMBL3143721 | — | — | 1 | 5.34 |
| CHEMBL3143723 | — | — | 1 | 5.27 |
| CHEMBL440560 | — | — | 1 | 4.80 |
| CHEMBL362016 | — | — | 1 | 4.75 |
| CHEMBL362455 | — | — | 1 | 4.64 |
| CHEMBL178397 | — | — | 1 | 4.62 |
| CHEMBL178133 | — | — | 1 | 4.34 |
| CHEMBL428861 | — | — | 1 | - |
| CHEMBL180580 | — | — | 1 | - |
| CHEMBL577792 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL271091 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL408151 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL258844 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL272292 | — | IC50 | = | 281.0 | nM | 6.55 |
| CHEMBL180231 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL178468 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL180058 | — | IC50 | = | 332.0 | nM | 6.48 |
| CHEMBL273160 | — | IC50 | = | 388.0 | nM | 6.41 |
| CHEMBL572629 | — | IC50 | = | 1179.0 | nM | 5.93 |
| CHEMBL3143722 | — | IC50 | = | 1755.0 | nM | 5.76 |
| CHEMBL181419 | — | IC50 | = | 1877.0 | nM | 5.73 |
| CHEMBL260397 | — | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL3143721 | — | IC50 | = | 4517.0 | nM | 5.34 |
| CHEMBL3143723 | — | IC50 | = | 5407.0 | nM | 5.27 |
| CHEMBL440560 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL362016 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL362455 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL178397 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL178133 | — | IC50 | = | 45270.0 | nM | 4.34 |
| CHEMBL428861 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL180580 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL577792 | — | IC50 | > | 50000.0 | nM | - |