Assay Detail
Binding
CHEMBL876992
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Inhibition of Phosphodiesterase 3
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.39 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL362451 | — | — | 1 | 6.24 |
| CHEMBL100503 | — | — | 1 | 5.53 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 5.16 |
| CHEMBL183726 | — | — | 1 | 4.63 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL362451 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL100503 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL183726 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL63 | ROLIPRAM | IC50 | > | 10000.0 | nM | - |