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Assay Detail

CHEMBL876995

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibitory concentration against Histone deacetylase; Control value 0.06 uM
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Histone deacetylase (CHEMBL2093865)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors.
Anandan SK, Ward JS, Brokx RD, Bray MR, Patel DV, Xiao XX.
Bioorg Med Chem Lett (2005) 15 : 1969 -1972
PubMed 15808449 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.35 6.18

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL194777 1 6.18
CHEMBL178202 1 5.96
CHEMBL195701 1 5.82
CHEMBL195261 1 5.63
CHEMBL195581 1 5.60
CHEMBL193979 1 5.55
CHEMBL194779 1 5.55
CHEMBL195513 1 5.51
CHEMBL193961 1 4.99
CHEMBL193959 1 4.90
CHEMBL193962 1 4.40
CHEMBL383587 1 4.16
CHEMBL2068713 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL194777 IC50 = 660.0 nM 6.18
CHEMBL178202 IC50 = 1100.0 nM 5.96
CHEMBL195701 IC50 = 1500.0 nM 5.82
CHEMBL195261 IC50 = 2350.0 nM 5.63
CHEMBL195581 IC50 = 2500.0 nM 5.60
CHEMBL193979 IC50 = 2800.0 nM 5.55
CHEMBL194779 IC50 = 2800.0 nM 5.55
CHEMBL195513 IC50 = 3100.0 nM 5.51
CHEMBL193961 IC50 = 10200.0 nM 4.99
CHEMBL193959 IC50 = 12500.0 nM 4.90
CHEMBL193962 IC50 = 39500.0 nM 4.40
CHEMBL383587 IC50 = 70000.0 nM 4.16
CHEMBL2068713 IC50 > 100000.0 nM -