Assay Detail
Binding
CHEMBL876996
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Inhibition of Cyclin-dependent kinase 5-p25nck5a
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.52 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 6.77 |
| CHEMBL31574 | FISETIN | 2.0 | 1 | 6.24 |
| CHEMBL28 | APIGENIN | — | 1 | 5.80 |
| CHEMBL117 | CHRYSIN | — | 1 | 5.51 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 5.42 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.64 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL31574 | FISETIN | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL28 | APIGENIN | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL117 | CHRYSIN | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL50 | QUERCETIN | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 51000.0 | nM | 4.29 |