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Assay Detail

CHEMBL877108

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Binding
Inhibitory constant towards dopamine D2 receptor was determined
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and binding affinity of novel 3-aminoethyl-1-tetralones, potential atypical antipsychotics.
Alvarado M, Coelho A, Masaguer CF, Raviña E, Brea J, Padín JF, Loza MI.
Bioorg Med Chem Lett (2005) 15 : 3063 -3066
PubMed 15878662 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 6.98 9.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL54 HALOPERIDOL 4.0 1 9.22
CHEMBL155486 1 7.24
CHEMBL191068 1 7.04
CHEMBL189213 1 6.97
CHEMBL155257 1 6.82
CHEMBL42 CLOZAPINE 4.0 1 6.65
CHEMBL190292 1 6.55
CHEMBL421801 1 6.34
CHEMBL365203 1 5.98
CHEMBL190509 1 -
CHEMBL189618 1 -
CHEMBL189562 1 -
CHEMBL191430 1 -
CHEMBL191408 1 -
CHEMBL190582 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL54 HALOPERIDOL Ki = 0.6026 nM 9.22
CHEMBL155486 Ki = 57.54 nM 7.24
CHEMBL191068 Ki = 91.2 nM 7.04
CHEMBL189213 Ki = 107.15 nM 6.97
CHEMBL155257 Ki = 151.36 nM 6.82
CHEMBL42 CLOZAPINE Ki = 223.87 nM 6.65
CHEMBL190292 Ki = 281.84 nM 6.55
CHEMBL421801 Ki = 457.09 nM 6.34
CHEMBL365203 Ki = 1047.13 nM 5.98
CHEMBL190509 Ki < 10000.0 nM -
CHEMBL189618 Ki < 10000.0 nM -
CHEMBL189562 Ki < 10000.0 nM -
CHEMBL191430 Ki < 10000.0 nM -
CHEMBL191408 Ki < 10000.0 nM -
CHEMBL190582 Ki < 10000.0 nM -