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Assay Detail

CHEMBL877209

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Functional
Antiviral activity against HRV-14 in cell culture
ChEMBL ↗
89
Total Activities
89
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism rhinovirus B14
Confidence 1 — Organism
Curated By Expert

Target

rhinovirus B14 (CHEMBL613759) ↗
Type ORGANISM
Organism rhinovirus B14

Publication

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 2. Peptide structure-activity studies.
Dragovich PS, Webber SE, Babine RE, Fuhrman SA, Patick AK, Matthews DA, Reich SH, Marakovits JT, Prins TJ, Zhou R, Tikhe J, Littlefield ES, Bleckman TM, Wallace MB, Little TL, Ford CE, Meador JW, Ferre RA, Brown EL, Binford SL, DeLisle DM, Worland ST.
J Med Chem (1998) 41 : 2819 -2834
PubMed 9667971 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 89 5.57 7.25

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL95145 — — 1 7.25
CHEMBL442961 — — 1 6.92
CHEMBL264798 — — 1 6.75
CHEMBL329262 — — 1 6.75
CHEMBL329409 — — 1 6.75
CHEMBL98400 — — 1 6.70
CHEMBL98344 — — 1 6.60
CHEMBL95030 — — 1 6.57
CHEMBL318130 — — 1 6.50
CHEMBL94057 — — 1 6.42
CHEMBL95182 — — 1 6.34
CHEMBL19648 — — 1 6.27
CHEMBL541463 — — 1 6.26
CHEMBL98727 — — 1 6.25
CHEMBL317502 — — 1 6.25
CHEMBL328467 — — 1 6.22
CHEMBL95300 — — 1 6.20
CHEMBL329557 — — 1 6.18
CHEMBL317932 — — 1 6.10
CHEMBL328871 — — 1 6.00
CHEMBL95015 — — 1 6.00
CHEMBL329700 — — 1 6.00
CHEMBL97036 — — 1 6.00
CHEMBL96534 — — 1 5.96
CHEMBL327369 — — 1 5.92
CHEMBL95059 — — 1 5.89
CHEMBL96192 — — 1 5.89
CHEMBL95473 — — 1 5.85
CHEMBL95053 — — 1 5.80
CHEMBL93865 — — 1 5.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL95145 — EC50 = 56.0 nM 7.25
CHEMBL442961 — EC50 = 120.0 nM 6.92
CHEMBL329262 — EC50 = 180.0 nM 6.75
CHEMBL329409 — EC50 = 180.0 nM 6.75
CHEMBL264798 — EC50 = 180.0 nM 6.75
CHEMBL98400 — EC50 = 200.0 nM 6.70
CHEMBL98344 — EC50 = 250.0 nM 6.60
CHEMBL95030 — EC50 = 270.0 nM 6.57
CHEMBL318130 — EC50 = 320.0 nM 6.50
CHEMBL94057 — EC50 = 380.0 nM 6.42
CHEMBL95182 — EC50 = 460.0 nM 6.34
CHEMBL19648 — EC50 = 540.0 nM 6.27
CHEMBL541463 — EC50 = 550.0 nM 6.26
CHEMBL317502 — EC50 = 560.0 nM 6.25
CHEMBL98727 — EC50 = 560.0 nM 6.25
CHEMBL328467 — EC50 = 600.0 nM 6.22
CHEMBL95300 — EC50 = 630.0 nM 6.20
CHEMBL329557 — EC50 = 660.0 nM 6.18
CHEMBL317932 — EC50 = 790.0 nM 6.10
CHEMBL328871 — EC50 = 1000.0 nM 6.00
CHEMBL95015 — EC50 = 1000.0 nM 6.00
CHEMBL329700 — EC50 = 1000.0 nM 6.00
CHEMBL97036 — EC50 = 1000.0 nM 6.00
CHEMBL96534 — EC50 = 1100.0 nM 5.96
CHEMBL327369 — EC50 = 1200.0 nM 5.92
CHEMBL95059 — EC50 = 1300.0 nM 5.89
CHEMBL96192 — EC50 = 1300.0 nM 5.89
CHEMBL95473 — EC50 = 1400.0 nM 5.85
CHEMBL95053 — EC50 = 1600.0 nM 5.80
CHEMBL93865 — EC50 = 1600.0 nM 5.80
CHEMBL97330 — EC50 = 1600.0 nM 5.80
CHEMBL94561 — EC50 = 1700.0 nM 5.77
CHEMBL328539 — EC50 = 1800.0 nM 5.75
CHEMBL95381 — EC50 = 1800.0 nM 5.75
CHEMBL93448 — EC50 = 1800.0 nM 5.75
CHEMBL1790765 — EC50 = 1800.0 nM 5.75
CHEMBL97486 — EC50 = 1900.0 nM 5.72
CHEMBL318223 — EC50 = 2000.0 nM 5.70
CHEMBL94557 — EC50 = 2200.0 nM 5.66
CHEMBL96856 — EC50 = 2400.0 nM 5.62
CHEMBL94659 — EC50 = 3500.0 nM 5.46
CHEMBL20668 — EC50 = 4000.0 nM 5.40
CHEMBL94645 — EC50 = 4500.0 nM 5.35
CHEMBL97527 — EC50 = 5000.0 nM 5.30
CHEMBL265277 — EC50 = 5100.0 nM 5.29
CHEMBL316456 — EC50 = 5200.0 nM 5.28
CHEMBL94663 — EC50 = 5200.0 nM 5.28
CHEMBL94160 — EC50 = 5300.0 nM 5.28
CHEMBL98560 — EC50 = 5400.0 nM 5.27
CHEMBL94848 — EC50 = 5500.0 nM 5.26