Assay Detail
ADMET
CHEMBL877269
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration which results in 50% survival of uninfected untreated control C8166 cells (cytotoxicity of the compound)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.54 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108221 | — | — | 1 | 4.77 |
| CHEMBL58711 | TIVIRAPINE | 2.0 | 1 | 4.30 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108221 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL58711 | TIVIRAPINE | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL129 | ZIDOVUDINE | IC50 | > | 100000.0 | nM | - |