Assay Detail
Binding
CHEMBL877453
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Binding affinity for mouse protein-tyrosine phosphatase 1B (PTP1B) expressed in COS 7 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | COS 7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL3336) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.11 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184444 | — | — | 1 | 6.04 |
| CHEMBL186337 | — | — | 1 | 5.68 |
| CHEMBL117869 | — | — | 1 | 5.16 |
| CHEMBL185872 | — | — | 1 | 4.94 |
| CHEMBL186989 | — | — | 1 | 4.64 |
| CHEMBL363687 | — | — | 1 | 4.22 |
| CHEMBL361485 | — | — | 1 | - |
| CHEMBL363229 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184444 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL186337 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL117869 | — | Ki | = | 6900.0 | nM | 5.16 |
| CHEMBL185872 | — | Ki | = | 11500.0 | nM | 4.94 |
| CHEMBL186989 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL363687 | — | Ki | = | 60300.0 | nM | 4.22 |
| CHEMBL361485 | — | Ki | = | 216000.0 | nM | - |
| CHEMBL363229 | — | Ki | = | 122000.0 | nM | - |