Assay Detail
Binding
CHEMBL877817
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Inhibitory activity against rat liver glycogen phosphorylase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Glycogen phosphorylase, liver form (CHEMBL3239) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
A new class of glycogen phosphorylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.42 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134152 | — | — | 1 | 7.80 |
| CHEMBL132201 | — | — | 1 | 7.72 |
| CHEMBL131644 | — | — | 1 | 7.62 |
| CHEMBL133745 | — | — | 1 | 6.52 |
| CHEMBL132640 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134152 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL132201 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL131644 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL133745 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL132640 | — | IC50 | < | 9.0 | nM | - |