Assay Detail
Binding
CHEMBL877837
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Inhibition of HIV-1 recombinant reverse transcriptase
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
1-Arylsulfonyl-3-(-hydroxybenzyl)-1H-pyrroles, a novel class of anti-HIV-1 reverse transcriptase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.11 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.60 |
| CHEMBL301449 | — | — | 1 | 5.60 |
| CHEMBL294602 | — | — | 1 | 5.33 |
| CHEMBL60866 | — | — | 1 | 5.19 |
| CHEMBL59133 | — | — | 1 | 4.77 |
| CHEMBL301913 | — | — | 1 | 4.75 |
| CHEMBL59226 | — | — | 1 | 4.66 |
| CHEMBL57709 | — | — | 1 | 4.57 |
| CHEMBL292808 | — | — | 1 | 4.53 |
| CHEMBL293538 | — | — | 1 | - |
| CHEMBL418282 | — | — | 1 | - |
| CHEMBL60805 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL301449 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL294602 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL60866 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL59133 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL301913 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL59226 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL57709 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL292808 | — | IC50 | = | 29500.0 | nM | 4.53 |
| CHEMBL293538 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL418282 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL60805 | — | IC50 | < | 1100.0 | nM | - |