Assay Detail
Functional
CHEMBL877973
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In vitro inhibition of hematin polymerization in Plasmodium falciparum
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Bisquinolines. 2. Antimalarial N,N-bis(7-chloroquinolin-4-yl)heteroalkanediamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.89 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL335524 | — | — | 1 | 5.16 |
| CHEMBL136459 | — | — | 1 | 4.82 |
| CHEMBL336448 | — | — | 1 | 4.70 |
| CHEMBL139165 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL335524 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL136459 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL336448 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL139165 | — | IC50 | > | 2500000.0 | nM | - |