Assay Detail
Binding
CHEMBL878147
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Affinity for the Human Dopamine receptor D4 was determined using membranes from CHO cells labeled with [3H]spiperone
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New generation dopaminergic agents. Part 8: heterocyclic bioisosteres that exploit the 7-OH-2-(aminomethyl)chroman D(2) template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.02 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420986 | — | — | 1 | 8.15 |
| CHEMBL93779 | — | — | 1 | 8.00 |
| CHEMBL313851 | — | — | 1 | 7.43 |
| CHEMBL64553 | — | — | 1 | 6.94 |
| CHEMBL93753 | — | — | 1 | 6.50 |
| CHEMBL303556 | — | — | 1 | 6.45 |
| CHEMBL60185 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420986 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL93779 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL313851 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL64553 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL93753 | — | Ki | = | 313.0 | nM | 6.50 |
| CHEMBL303556 | — | Ki | = | 359.0 | nM | 6.45 |
| CHEMBL60185 | — | Ki | = | 2174.0 | nM | 5.66 |