Assay Detail
Binding
CHEMBL878194
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested in vitro for binding affinity against histamine H1 receptor from guinea pig cerebellum, using [3H]pyrilamine as radioligand at 0.1 uM
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cerebellum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and antiallergic activity of 11-(aminoalkylidene)-6,11-dihydrodibenz[b,e]oxepin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.55 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL534 | KETOTIFEN | 4.0 | 1 | 9.51 |
| CHEMBL294777 | — | — | 1 | 9.20 |
| CHEMBL294345 | — | — | 1 | 8.24 |
| CHEMBL302005 | — | — | 1 | 7.96 |
| CHEMBL62790 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL534 | KETOTIFEN | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL294777 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL294345 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL302005 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL62790 | — | Ki | = | 15.0 | nM | 7.82 |