Assay Detail
Binding
CHEMBL878397
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Apparent binding constant Ki=Kon/Koff
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A comparative SAR and computer modeling study of benzisothiazolone, mechanism-based inhibitors with porcine pancreatic and human leukocyte elastase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 8.53 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98422 | — | — | 1 | 9.57 |
| CHEMBL50974 | — | — | 1 | 9.52 |
| CHEMBL319723 | — | — | 1 | 9.22 |
| CHEMBL50830 | — | — | 1 | 9.22 |
| CHEMBL299656 | — | — | 1 | 9.15 |
| CHEMBL296159 | — | — | 1 | 8.70 |
| CHEMBL100620 | — | — | 1 | 8.70 |
| CHEMBL432890 | — | — | 1 | 7.87 |
| CHEMBL323545 | — | — | 1 | 7.84 |
| CHEMBL50803 | — | — | 1 | 7.82 |
| CHEMBL300307 | — | — | 1 | 7.50 |
| CHEMBL298107 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98422 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL50974 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL319723 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL50830 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL299656 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL296159 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL100620 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL432890 | — | Ki | = | 13.6 | nM | 7.87 |
| CHEMBL323545 | — | Ki | = | 14.5 | nM | 7.84 |
| CHEMBL50803 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL300307 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL298107 | — | Ki | = | 60.0 | nM | 7.22 |