Assay Detail
Binding
CHEMBL878432
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against Holo-[acyl-carrier-protein] synthase was determined using Bacillus subtilis GST-Acp-HTRFassay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus subtilis |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Holo-[acyl-carrier-protein] synthase (CHEMBL4734) ↗| Type | SINGLE PROTEIN |
| Organism | Bacillus subtilis (strain 168) |
Publication
Anthranilate 4H-oxazol-5-ones: novel small molecule antibacterial acyl carrier protein synthase (AcpS) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.70 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL130657 | — | — | 1 | 6.89 |
| CHEMBL335756 | — | — | 1 | 6.57 |
| CHEMBL130683 | — | — | 1 | 6.08 |
| CHEMBL130278 | — | — | 1 | 5.96 |
| CHEMBL130832 | — | — | 1 | 5.89 |
| CHEMBL129980 | — | — | 1 | 5.82 |
| CHEMBL130279 | — | — | 1 | 5.72 |
| CHEMBL435599 | — | — | 1 | 5.70 |
| CHEMBL339848 | — | — | 1 | 5.68 |
| CHEMBL339849 | — | — | 1 | 5.47 |
| CHEMBL132893 | — | — | 1 | 4.82 |
| CHEMBL133301 | — | — | 1 | 4.82 |
| CHEMBL133577 | — | — | 1 | 4.70 |
| CHEMBL133468 | — | — | 1 | - |
| CHEMBL131492 | — | — | 1 | - |
| CHEMBL134062 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL130657 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL335756 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL130683 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL130278 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL130832 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL129980 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL130279 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL435599 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL339848 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL339849 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL132893 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL133301 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL133577 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL133468 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL131492 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL134062 | — | IC50 | > | 20000.0 | nM | - |