Assay Detail
Binding
CHEMBL878537
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against HIV-1 Reverse transcriptase (RT) was determined
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
The synthesis of a dipyrido[3,2-b:3,4-e][1,4]diazepinone: Convenient access to a C-ring isomer of the HIV-1 reverse transcriptase inhibitor nevirapine
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.22 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.08 |
| CHEMBL37343 | — | — | 1 | 6.90 |
| CHEMBL289038 | — | — | 1 | 6.46 |
| CHEMBL298243 | — | — | 1 | 5.89 |
| CHEMBL42656 | — | — | 1 | 5.80 |
| CHEMBL46562 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL37343 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL289038 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL298243 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL42656 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL46562 | — | IC50 | = | 6400.0 | nM | 5.19 |