Assay Detail
Functional
CHEMBL878747
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Inhibition of tubulin polymerization (ITP)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.29 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50613 | — | — | 1 | 5.77 |
| CHEMBL50958 | — | — | 1 | 5.77 |
| CHEMBL51083 | — | — | 1 | 5.57 |
| CHEMBL296839 | — | — | 1 | 5.55 |
| CHEMBL49517 | — | — | 1 | 5.42 |
| CHEMBL412886 | — | — | 1 | 5.32 |
| CHEMBL48653 | — | — | 1 | 5.22 |
| CHEMBL46011 | — | — | 1 | 5.16 |
| CHEMBL336214 | — | — | 1 | 5.11 |
| CHEMBL334478 | — | — | 1 | 4.89 |
| CHEMBL130391 | — | — | 1 | 4.85 |
| CHEMBL340282 | — | — | 1 | 4.85 |
| CHEMBL133300 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50613 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL50958 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL51083 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL296839 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL49517 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL412886 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL48653 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL46011 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL336214 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL334478 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL130391 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL340282 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL133300 | — | IC50 | > | 40000.0 | nM | - |