Assay Detail
Binding
CHEMBL878776
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Effective concentration of compound for inhibition of HIV 1 protease was determined
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Application of the three-dimensional structures of protein target molecules in structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.14 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3350055 | — | — | 1 | 7.70 |
| CHEMBL3350059 | — | — | 1 | 7.30 |
| CHEMBL43294 | — | — | 1 | 7.22 |
| CHEMBL73050 | A-77003 | — | 1 | 7.16 |
| CHEMBL3350051 | — | — | 1 | 6.92 |
| CHEMBL406493 | A-76928 | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3350055 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3350059 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL43294 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL73050 | A-77003 | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3350051 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL406493 | A-76928 | EC50 | = | 280.0 | nM | 6.55 |