Assay Detail
Binding
CHEMBL878978
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Trypsin
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and structure-activity relationships of unsubstituted piperazinone-based transition state factor Xa inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.01 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL352039 | — | — | 1 | 9.10 |
| CHEMBL355376 | — | — | 1 | 8.70 |
| CHEMBL159695 | — | — | 1 | 7.97 |
| CHEMBL423810 | — | — | 1 | 7.70 |
| CHEMBL350587 | — | — | 1 | 7.69 |
| CHEMBL162461 | — | — | 1 | 7.48 |
| CHEMBL163174 | — | — | 1 | 7.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL352039 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL355376 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL159695 | — | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL423810 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL350587 | — | IC50 | = | 20.5 | nM | 7.69 |
| CHEMBL162461 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL163174 | — | IC50 | = | 39.1 | nM | 7.41 |