Assay Detail
Binding
CHEMBL879076
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibition of hog kidney renin
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Kidney |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A uniquely potent renin inhibitor and its unanticipated plasma binding component.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.03 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL424543 | — | — | 1 | 7.75 |
| CHEMBL3144406 | — | — | 1 | 7.72 |
| CHEMBL40928 | — | — | 1 | 7.06 |
| CHEMBL3144405 | — | — | 1 | 6.57 |
| CHEMBL3144404 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL424543 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3144406 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL40928 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL3144405 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL3144404 | — | IC50 | = | 858.0 | nM | 6.07 |