Assay Detail
Binding
CHEMBL879077
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Compound was tested for inhibition of human plasma renin
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A uniquely potent renin inhibitor and its unanticipated plasma binding component.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.84 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3144406 | — | — | 1 | 8.05 |
| CHEMBL3144405 | — | — | 1 | 7.60 |
| CHEMBL3144404 | — | — | 1 | 6.00 |
| CHEMBL424543 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3144406 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3144405 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3144404 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL424543 | — | IC50 | = | 1900.0 | nM | 5.72 |