Assay Detail
Functional
CHEMBL879280
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Antagonistic potency for NK-1 receptor was determined in vitro, using isolated rabbit vena cava.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Vena cava |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The dipeptide neurokinin-1 receptor antagonist S19752 is a potent and long-acting inhibitor of bronchoconstriction when administered by aerosol to the guinea pig in vivo
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 8.65 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441225 | CP-99994 | — | 1 | 8.90 |
| CHEMBL22870 | L-732138 | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441225 | CP-99994 | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL22870 | L-732138 | Kd | = | 3.981 | nM | 8.40 |