Assay Detail
Binding
CHEMBL879331
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against HIV-1 protease expressed in Escherichia coli
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and fast synthesis of C-terminal duplicated potent C(2)-symmetric P1/P1'-modified HIV-1 protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 9.23 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127045 | — | — | 1 | 10.05 |
| CHEMBL124139 | — | — | 1 | 9.52 |
| CHEMBL338428 | — | — | 1 | 9.52 |
| CHEMBL123850 | — | — | 1 | 9.52 |
| CHEMBL105459 | — | — | 1 | 9.40 |
| CHEMBL340116 | — | — | 1 | 9.22 |
| CHEMBL127524 | — | — | 1 | 9.22 |
| CHEMBL125420 | — | — | 1 | 9.15 |
| CHEMBL127214 | — | — | 1 | 8.92 |
| CHEMBL333399 | — | — | 1 | 8.92 |
| CHEMBL264815 | — | — | 1 | 8.85 |
| CHEMBL441167 | — | — | 1 | 8.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127045 | — | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL124139 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL338428 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL123850 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL105459 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL340116 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL127524 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL125420 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL127214 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL333399 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL264815 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL441167 | — | Ki | = | 3.8 | nM | 8.42 |