Assay Detail
Functional
CHEMBL879379
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against growth of HT-29 cell line
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of chimeric structures derived from the cytotoxic natural compounds dolastatin 10 and dolastatin 15.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.56 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39541 | DOLASTATIN-10 | 2.0 | 1 | 10.22 |
| CHEMBL35769 | DOLASTATIN 15 | — | 1 | 9.54 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 8.69 |
| CHEMBL37030 | — | — | 1 | 7.94 |
| CHEMBL608244 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39541 | DOLASTATIN-10 | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL35769 | DOLASTATIN 15 | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 2.06 | nM | 8.69 |
| CHEMBL37030 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL608244 | — | IC50 | = | 396.0 | nM | 6.40 |