Assay Detail
Functional
CHEMBL879465
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Chemosensitivity against DT-diaphorase rich H29 cell lines
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Bioreductive activation of a series of indolequinones by human DT-diaphorase: structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.90 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74816 | — | — | 1 | 7.41 |
| CHEMBL308775 | — | — | 1 | 7.21 |
| CHEMBL73822 | APAZIQUONE | 3.0 | 1 | 6.91 |
| CHEMBL307665 | — | — | 1 | 6.15 |
| CHEMBL328535 | — | — | 1 | 6.11 |
| CHEMBL329024 | — | — | 1 | 6.05 |
| CHEMBL341425 | — | — | 1 | 6.00 |
| CHEMBL338716 | — | — | 1 | 5.92 |
| CHEMBL306559 | — | — | 1 | 5.86 |
| CHEMBL328916 | — | — | 1 | 5.82 |
| CHEMBL77393 | — | — | 1 | 5.68 |
| CHEMBL130223 | — | — | 1 | 5.66 |
| CHEMBL307888 | — | — | 1 | 5.61 |
| CHEMBL94033 | — | — | 1 | 5.24 |
| CHEMBL130409 | — | — | 1 | 5.17 |
| CHEMBL131446 | — | — | 1 | 4.87 |
| CHEMBL112472 | — | — | 1 | 4.58 |
| CHEMBL335032 | — | — | 1 | - |
| CHEMBL93641 | — | — | 1 | - |
| CHEMBL73067 | — | — | 1 | - |
| CHEMBL133323 | — | — | 1 | - |
| CHEMBL133390 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74816 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL308775 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL73822 | APAZIQUONE | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL307665 | — | IC50 | = | 715.0 | nM | 6.15 |
| CHEMBL328535 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL329024 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL341425 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL338716 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL306559 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL328916 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL77393 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL130223 | — | IC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL307888 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL94033 | — | IC50 | = | 5730.0 | nM | 5.24 |
| CHEMBL130409 | — | IC50 | = | 6840.0 | nM | 5.17 |
| CHEMBL131446 | — | IC50 | = | 13530.0 | nM | 4.87 |
| CHEMBL112472 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL335032 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL93641 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL73067 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL133323 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL133390 | — | IC50 | > | 40000.0 | nM | - |