Assay Detail
Binding
CHEMBL879486
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Inhibition of N-terminally truncated recombinant human dihydroorotate dehydrogenase using in vitro enzyme assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL1966) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.91 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL194955 | — | — | 1 | 8.40 |
| CHEMBL154623 | — | — | 1 | 8.15 |
| CHEMBL193365 | — | — | 1 | 7.96 |
| CHEMBL195622 | — | — | 1 | 7.96 |
| CHEMBL194075 | — | — | 1 | 7.82 |
| CHEMBL157105 | — | — | 1 | 7.48 |
| CHEMBL193371 | — | — | 1 | 7.39 |
| CHEMBL194954 | — | — | 1 | 7.24 |
| CHEMBL194776 | — | — | 1 | 6.98 |
| CHEMBL196181 | — | — | 1 | 6.96 |
| CHEMBL197553 | — | — | 1 | 6.90 |
| CHEMBL194023 | — | — | 1 | 6.88 |
| CHEMBL197194 | VIDOFLUDIMUS | 3.0 | 1 | 6.87 |
| CHEMBL195246 | — | — | 1 | 6.76 |
| CHEMBL195163 | — | — | 1 | 6.69 |
| CHEMBL197455 | — | — | 1 | 6.44 |
| CHEMBL348270 | — | — | 1 | 6.39 |
| CHEMBL973 | TERIFLUNOMIDE | 4.0 | 1 | 6.38 |
| CHEMBL372101 | — | — | 1 | 6.18 |
| CHEMBL194395 | — | — | 1 | 6.17 |
| CHEMBL196256 | — | — | 1 | 5.84 |
| CHEMBL370008 | — | — | 1 | 5.70 |
| CHEMBL196173 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL194955 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL154623 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL193365 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL195622 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL194075 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL157105 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL193371 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL194954 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL194776 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL196181 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL197553 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL194023 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL197194 | VIDOFLUDIMUS | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL195246 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL195163 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL197455 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL348270 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL973 | TERIFLUNOMIDE | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL372101 | — | IC50 | = | 667.0 | nM | 6.18 |
| CHEMBL194395 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL196256 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL370008 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL196173 | — | IC50 | = | 3800.0 | nM | 5.42 |