Assay Detail
Functional
CHEMBL879579
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Compound concentration required to inhibit the viral cell proliferation by 50% against HBV
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of a series of 2'-fluorinated-2',3'-dideoxy-2',3'-didehydro-(L)-nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.69 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38700 | ELVUCITABINE | 2.0 | 1 | 8.10 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 7.52 |
| CHEMBL40724 | — | — | 1 | 7.44 |
| CHEMBL38887 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38700 | ELVUCITABINE | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL40724 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL38887 | — | EC50 | > | 30.0 | nM | - |