Assay Detail
Binding
CHEMBL879724
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Concentration required for in vitro inhibitory activity against HIV-1 protease
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
D-amino acids as novel P2/P3 ligands for inhibitors of HIV-1 protease
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.91 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282787 | — | — | 1 | 8.82 |
| CHEMBL429036 | — | — | 1 | 8.27 |
| CHEMBL407052 | — | — | 1 | 8.10 |
| CHEMBL268605 | — | — | 1 | 7.29 |
| CHEMBL11193 | — | — | 1 | 7.07 |
| CHEMBL24442 | — | — | 1 | - |
| CHEMBL31266 | — | — | 1 | - |
| CHEMBL441894 | — | — | 1 | - |
| CHEMBL10890 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282787 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL429036 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL407052 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL268605 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL11193 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL24442 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL31266 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL441894 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL10890 | — | IC50 | > | 1000.0 | nM | - |