Assay Detail
Functional
CHEMBL879733
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Concentration that reduces difference in reversal of [3H]VBL accumulation between MDA-435/LCC6 and MDA-435/LCC6-MDRI cells by 50%
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Breast cancer cell line |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
C-7 analogues of progesterone as potent inhibitors of the P-glycoprotein efflux pump.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.63 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 6.22 |
| CHEMBL131172 | — | — | 1 | 6.10 |
| CHEMBL419965 | — | — | 1 | 6.10 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 5.92 |
| CHEMBL338904 | — | — | 1 | 5.89 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 4.73 |
| CHEMBL129251 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL131172 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL419965 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL6966 | VERAPAMIL | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL338904 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL103 | PROGESTERONE | EC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL129251 | — | EC50 | = | 34800.0 | nM | 4.46 |