Assay Detail
Functional
CHEMBL879742
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested against MXF7 breast carcinoma (sensitive) cell line in the sulforhodamine B assay.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
6- and 7-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h] isoquinoline-1,3-diones: synthesis, nucleophilic displacements, antitumor activity, and quantitative structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.78 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44207 | — | — | 1 | 9.00 |
| CHEMBL40515 | — | — | 1 | 8.41 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 8.06 |
| CHEMBL43809 | — | — | 1 | 8.00 |
| CHEMBL43931 | — | — | 1 | 7.96 |
| CHEMBL40865 | — | — | 1 | 7.96 |
| CHEMBL42100 | — | — | 1 | 7.85 |
| CHEMBL42490 | — | — | 1 | 7.75 |
| CHEMBL290677 | AZONAFIDE | — | 1 | 7.75 |
| CHEMBL40716 | — | — | 1 | 7.70 |
| CHEMBL42201 | — | — | 1 | 7.70 |
| CHEMBL40924 | — | — | 1 | 7.64 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.55 |
| CHEMBL288699 | — | — | 1 | 7.17 |
| CHEMBL289120 | — | — | 1 | 7.10 |
| CHEMBL288217 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44207 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL40515 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL43809 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL43931 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL40865 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL42100 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL42490 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL290677 | AZONAFIDE | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL40716 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL42201 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL40924 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL288699 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL289120 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL288217 | — | IC50 | = | 150.0 | nM | 6.82 |