Assay Detail
Binding
CHEMBL879873
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Binding affinity towards human Dopamine receptor D4.2 evaluated using [3H]spiperone
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification, characterization and pharmacological profile of three metabolites of (R)-(+)-1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenylcyclohexen-1- yl)methyl]pyridine (CI-1007), a dopamine autoreceptor agonist and potential antipsychotic agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.14 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL357416 | — | — | 1 | 7.21 |
| CHEMBL147159 | — | — | 1 | 7.17 |
| CHEMBL335545 | CI-1007 | — | 1 | 7.04 |
| CHEMBL356269 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL357416 | — | Ki | = | 61.4 | nM | 7.21 |
| CHEMBL147159 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL335545 | CI-1007 | Ki | = | 90.9 | nM | 7.04 |
| CHEMBL356269 | — | Ki | > | 10000.0 | nM | - |