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Assay Detail

CHEMBL879942

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity tests were performed on a human diploid embryonic lung cell line (MRC5) using the colorimetric MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MRC5
Confidence 1 — Organism
Curated By Expert

Target

MRC5 (CHEMBL614181)
Type CELL-LINE
Organism Homo sapiens

Publication

Parallel synthesis and anti-malarial activity of a sulfonamide library.
Ryckebusch A, Déprez-Poulain R, Debreu-Fontaine MA, Vandaele R, Mouray E, Grellier P, Sergheraert C.
Bioorg Med Chem Lett (2002) 12 : 2595 -2598
PubMed 12182868 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.61 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL328265 1 6.00
CHEMBL86727 1 6.00
CHEMBL87198 1 6.00
CHEMBL89242 1 6.00
CHEMBL315677 1 6.00
CHEMBL89645 1 6.00
CHEMBL89861 1 5.70
CHEMBL431084 1 5.52
CHEMBL422953 1 5.40
CHEMBL312850 1 5.40
CHEMBL86739 1 5.40
CHEMBL86622 1 5.22
CHEMBL76 CHLOROQUINE 4.0 1 4.30
CHEMBL87431 1 -
CHEMBL315975 1 -
CHEMBL87110 1 -
CHEMBL89732 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL328265 IC50 = 1000.0 nM 6.00
CHEMBL86727 IC50 = 1000.0 nM 6.00
CHEMBL87198 IC50 = 1000.0 nM 6.00
CHEMBL89242 IC50 = 1000.0 nM 6.00
CHEMBL315677 IC50 = 1000.0 nM 6.00
CHEMBL89645 IC50 = 1000.0 nM 6.00
CHEMBL89861 IC50 = 2000.0 nM 5.70
CHEMBL431084 IC50 = 3000.0 nM 5.52
CHEMBL422953 IC50 = 4000.0 nM 5.40
CHEMBL312850 IC50 = 4000.0 nM 5.40
CHEMBL86739 IC50 = 4000.0 nM 5.40
CHEMBL86622 IC50 = 6000.0 nM 5.22
CHEMBL76 CHLOROQUINE IC50 = 50000.0 nM 4.30
CHEMBL87431 IC50 < 3000.0 nM -
CHEMBL315975 IC50 < 3000.0 nM -
CHEMBL87110 IC50 < 3000.0 nM -
CHEMBL89732 IC50 < 3000.0 nM -