Assay Detail
Binding
CHEMBL879983
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Inhibition of Neisseria gonorrhoeae Dihydrofolate reductase(DHFR)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Neisseria gonorrhoeae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 9. Lipophilic trimethoprim analogues as antigonococcal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.04 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24503 | — | — | 1 | 7.70 |
| CHEMBL440946 | — | — | 1 | 7.54 |
| CHEMBL279455 | — | — | 1 | 7.36 |
| CHEMBL25888 | — | — | 1 | 7.31 |
| CHEMBL24374 | — | — | 1 | 7.24 |
| CHEMBL277176 | — | — | 1 | 7.21 |
| CHEMBL278345 | — | — | 1 | 7.17 |
| CHEMBL23338 | — | — | 1 | 7.03 |
| CHEMBL282022 | — | — | 1 | 6.96 |
| CHEMBL25817 | — | — | 1 | 6.92 |
| CHEMBL23609 | — | — | 1 | 6.77 |
| CHEMBL23447 | — | — | 1 | 6.51 |
| CHEMBL287553 | — | — | 1 | 6.43 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24503 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL440946 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL279455 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL25888 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL24374 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL277176 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL278345 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL23338 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL282022 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL25817 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL23609 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL23447 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL287553 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 450.0 | nM | 6.35 |