Assay Detail
Binding
CHEMBL879985
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Inhibition of dihydrofolate reductase (DHFR) in WIL2 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | WIL2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 5-deazaisofolic acid, 5-deaza-5,6,7,8-tetrahydroisofolic acid, and their N9-substituted analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.33 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157857 | — | — | 1 | 6.68 |
| CHEMBL156551 | — | — | 1 | 6.60 |
| CHEMBL157775 | — | — | 1 | 5.71 |
| CHEMBL13659 | — | — | 1 | - |
| CHEMBL157230 | — | — | 1 | - |
| CHEMBL170101 | — | — | 1 | - |
| CHEMBL156308 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157857 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL156551 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL157775 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL13659 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL157230 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL170101 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL156308 | — | IC50 | > | 1000000.0 | nM | - |