Assay Detail
Binding
CHEMBL880029
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Inhibition of solubilized, purified rat liver HMG-CoA reductase.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL3247) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side chain ester derivatives of mevinolin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 8.08 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3349544 | — | — | 1 | 9.05 |
| CHEMBL3349956 | — | — | 1 | 8.85 |
| CHEMBL3349944 | — | — | 1 | 8.85 |
| CHEMBL3349955 | — | — | 1 | 8.72 |
| CHEMBL333443 | — | — | 1 | 8.66 |
| CHEMBL3349951 | — | — | 1 | 8.66 |
| CHEMBL3349950 | — | — | 1 | 8.57 |
| CHEMBL3349954 | — | — | 1 | 8.54 |
| CHEMBL3349952 | — | — | 1 | 8.46 |
| CHEMBL3349946 | — | — | 1 | 8.42 |
| CHEMBL3349949 | — | — | 1 | 8.27 |
| CHEMBL3349960 | — | — | 1 | 8.11 |
| CHEMBL3349958 | — | — | 1 | 8.06 |
| CHEMBL3085466 | — | — | 1 | 7.72 |
| CHEMBL3349945 | — | — | 1 | 7.56 |
| CHEMBL3349948 | — | — | 1 | 7.43 |
| CHEMBL3349953 | — | — | 1 | 7.41 |
| CHEMBL3349947 | — | — | 1 | 7.08 |
| CHEMBL3349957 | — | — | 1 | 6.57 |
| CHEMBL3349959 | — | — | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3349544 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL3349956 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3349944 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3349955 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL333443 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3349951 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3349950 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3349954 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL3349952 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3349946 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL3349949 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL3349960 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL3349958 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL3085466 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3349945 | — | IC50 | = | 27.3 | nM | 7.56 |
| CHEMBL3349948 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3349953 | — | IC50 | = | 38.6 | nM | 7.41 |
| CHEMBL3349947 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL3349957 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL3349959 | — | IC50 | = | 295.0 | nM | 6.53 |