Assay Detail
Functional
CHEMBL880109
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Cytotoxicity against H 460 human lung cancer cell line
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
N-methylcarbamate derivatives of ellipticine and olivacine with cytotoxic activity against four human lung cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.49 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144698 | — | — | 1 | 7.70 |
| CHEMBL142232 | — | — | 1 | 7.22 |
| CHEMBL144606 | — | — | 1 | 7.16 |
| CHEMBL19569 | — | — | 1 | 6.77 |
| CHEMBL142242 | — | — | 1 | 6.02 |
| CHEMBL145377 | — | — | 1 | 5.77 |
| CHEMBL144783 | — | — | 1 | 5.72 |
| CHEMBL26559 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144698 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL142232 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL144606 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL19569 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL142242 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL145377 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL144783 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL26559 | — | IC50 | = | 2600.0 | nM | 5.58 |